Journal: Journal of Inflammation Research

Article Title: Chrysoeriol Alleviates Psoriasis Inflammation and Keratinocyte Hyperproliferation Possibly Through Inhibiting AKT/NF-κB Signaling Activation

doi: 10.2147/JIR.S609042

Figure Lengend Snippet: CHR ameliorated psoriatic skin lesions induced by IMQ in mice. ( A ) Experimental design: After dorsal shaving, mice (except controls) received daily 62.5 mg IMQ (days 1–6). The DXMS group got 26 mg dexamethasone, while the CHR group received CHR treatment. ( B ) Dorsal skin photographs from each group (n=5) were taken on day 6. ( C ) Psoriasis Area Severity Index (PASI) scores were assessed. ( D – F ) Daily scoring of scaling, epidermal thickening, and erythema was performed. ( G ) Splenic index was calculated for all groups. P values were calculated using one-way or two-way ANOVA followed by Turkey’s test. (Mean ± SD; vs CON, #### p<0.0001; vs IMQ, *p<0.05, **p<0.01, ***p<0.001).

Article Snippet: The positive drug dexamethasone acetate and 2 mg/mL CHR (Cat. No. HY-121471, MCE, USA, purity ≥98%) were prepared with propylene glycol and topically administrated correspondingly.

Techniques:

Journal: Materials Today Bio

Article Title: Enhancing the therapeutic efficacy of dexamethasone for oral ulcers through adhesive gelatin hydrogel-based nano-delivery system

doi: 10.1016/j.mtbio.2026.103341

Figure Lengend Snippet: Therapeutic efficacy of gelatin hydrogel loaded with PDA-Dex-PAN on rat oral ulcers. (a) Schematic diagram of oral ulcer induction and drug administration in rat. (b) Therapeutic effects of different dexamethasone formulations on rat oral ulcers. A total of six replicates are present. The figure above shows three of them, and the other three replicates are provided in Serum levels of inflammatory cytokines, including IL-6 (c), TNF-α (d), and IL-1β (e), in rats after treatment with different dexamethasone formulations. The data are represented as mean ± SD (n = 6). The difference analyses were performed using the Student's t-test, and the significance was indicated by one asterisk for p < 0.05 and two asterisks for p < 0.01. (f) H&E staining observation of the ulcer sites in rat oral mucosa after treatment with different dexamethasone formulations.

Article Snippet: The following reagents were obtained from the specified suppliers: dexamethasone (Dex), rhodamine (RhB) and dopamine (PDA) from Shanghai Yuanye Biological Technology Co., Ltd. (Shanghai, China); gelatin (Type B), poly-L-lysine (PLL), and polyethylene glycol (PEG6000) from Aladdin Bio-Chem Technology Co., Ltd. (Shanghai, China); glycine from Shanghai Sangon (Shanghai, China); polylactic acid (Mw 18-24 kDa), 4′,6-Diamidino-2-phenylindole (DAPI), phosgene, 2-hydroxyethyl disulfide, THF, NHS ester, and triethylamine from Sigma-Aldrich (St. Louis, USA).

Techniques: Drug discovery, Staining